Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets beta-amyloid (Abeta) reactions with synaptic Zn and Cu yet promotes metal uptake. Here we characterize the second-generation 8-hydroxy quinoline analog PBT2, which also targets metal-induced aggregation of Abeta, but is more effective as a Zn/Cu ionophore and has greater blood-brain barrier permeability. Given...

Decreased Plasma Aβ in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction

Besides the continued focus on Aβ and Tau in Alzheimer's disease (AD), it is increasingly evident that other pathologic characteristics, such as vascular alterations or inflammation, are associated with AD. Whether these changes are an initial cause for the onset of AD or occur as a result of the disease in late stages is still under debate. In the present study, the impact of the high-fat diet...

Effects of hyperoxia in alzheimers transgenic mice

evaluation of fat atrophy in patients with dermis fat graft of orbit by ct-scan

چکیده ندارد.

CORRIGENDUM: SERPINB3 is associated with longer survival in transgenic mice

Marika Crescenzi was omitted from the author list in the original version of this Article. This has been corrected in the PDF and HTML versions of the Article. The Author Contributions section should read ‘‘G.V. designed and performed the experiments, analyzed data and drafted the manuscript, M.R., G.C., C.T., A.C. preformed molecular biology experiments, S.Q., A.B. performed cell culture andwe...